“When someone says of an obese person, ‘They should just eat less and exercise more,’ I say if it were that simple, obesity wouldn’t be the worldwide epidemic that it is.” That’s according to Dr. Claude Bouchard, a faculty fellow of the Texas A&M University Institute for Advanced Study (TIAS), a program that attracts eminent scholars from around the world for extended stays to study, teach and conduct research alongside Texas A&M students and faculty.
Bouchard, director of the Human Genomics Lab at Pennington Biomedical Research Center in Baton Rouge, La., studies the genetics of obesity and says there are dozens of factors involved in determining whether or not a person becomes overweight or obese.
“It’s a complex problem because there are so many drivers,” says Bouchard, author or coauthor of several books and more than 1,000 scientific papers, and a former president of the International Association for the Study of Obesity. “Approaches focus on only a few and forget that while we control them there is compensation taking place elsewhere; there are other drivers that come into play.”
He divides those drivers into four categories: social, environmental, behavioral and biological.
Social factors include less access to nutritious foods, more recreational eating, powerful and constant advertising, large food portions, poor school meals, eating on the run, food pricing and fewer meals cooked at home.
Our physical environment affects eating habits as well, says Bouchard, such as the absence of sidewalks, reliance on automobiles, building design and environmental pollutants.
Behavioral factors such as spending less time in strenuous activity, taking medications known to increase body weight, the absence of breast-feeding, eating corn fructose syrup, an increase in sedentary jobs and high-fat diets.
And biological factors such as genetics, viruses, gut microbiota (microorganisms living in the intestine), adipose tissue (body fat) biology, and metabolic rates can all affect weight and many are not within a person’s control.
“The biology is very complex,” Bouchard notes. “The response to environmental, social and behavioral factors is conditional on the genotype of an individual. Your adaptation to a diet or a given amount of exercise is determined by your genes.”
More research is needed, he says, but there is a strong probability that diet and exercise programs for weight control or disease prevention will one day be tailored to an individual’s genetic makeup. He asks, “Can we meet the challenge of identifying genomic predictors of the ability of a given person to respond favorably to a specific combination of food and exercise? I believe that we can.”
Bouchard and his colleague, Dr. George Bray, have edited the latest version of the “Handbook of Obesity,” the definitive guide on the subject, which thoroughly discusses the many contributing factors, treatment and prevention of this chronic disease.
Bouchard will continue his studies through TIAS, returning to Texas A&M in May, September and October to continue working on research grant applications, ongoing studies and on scientific papers with colleagues and students from the Department of Health & Kinesiology and the Center for Translational Research in Aging and Longevity.
The Texas A&M Institute for Advanced Study is in its second year. Its first two classes include four recipients of the highest honors for scholarship: two Nobel Prize winners, a National Medal of Science winner, and a Wolf Prize recipient, as well as many national and international academy members and top literary scholars. Like Claude Bouchard, all of the TIAS Faculty Fellows are collaborating with Texas A&M faculty and graduate students to solve important world problems. Visit tias.tamu.edu for more information.
About Research at Texas A&M University: As one of the world’s leading research institutions, Texas A&M is in the vanguard in making significant contributions to the storehouse of knowledge, including that of science and technology. Research conducted at Texas A&M represents annual expenditures of more than $820 million. That research creates new knowledge that provides basic, fundamental and applied contributions resulting in many cases in economic benefits to the state, nation and world. To learn more, visit http://research.tamu.edu.
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